Resume

Summary

A preclinical scientist with over 20 years of in vivo pharmacological experience in the biopharmaceutical industry. Strong reputation for leading preclinical studies from first-in-class to best-in-drug medicines for unmet medical needs. Especially adept at: In vivo cardiovascular models Surgical expertise Team building Protocol/Scientific writing Basic and advanced laboratory training Product Development Skilled in training and mentoring laboratory staff to achieve project goals and compliance.

Professional Experience

Theravance, Inc., South San Francisco, CA 1999 to Present
Scientist, Pharmacology Department

Organized a cardiovascular laboratory to evaluate the preclinical safety and hemodynamic profiles of asthma, overactive bladder, anti-infective and antihypertensive drug candidates. Championed an exploratory project, which is currently in preclinical development. Provided key data, which resulted into two business partnerships with major pharmaceutical companies.

 Championed an exploratory project currently in preclinical development.

 Designed preclinical cardiovascular studies that resulted into two business partnerships with major pharmaceutical companies; leading to milestone payments to the company.

 Served as a principal investigator in 12 approved protocols.

 Monitored an online training module for staff in pharmacology which led to initiation of an intranet training website for the entire department, saving thousands of dollars in outside training.

 Designed and implemented preclinical cardiovascular models to evaluate standard and novel molecules in asthma, overactive bladder and hypertension.

 Developed and validated rat model of acute decompensated heart failure; influenced and introduced a new direction to the critical path for the project.

 Implemented safety models, cough and angioedema; instilled a level of confidence that our molecules would have therapeutic benefits without the clinical risk.

 Applied surgical expertise to developed acute and conscious models to evaluate bladder function.

 Monitored new advances in data acquisition, physiological monitoring and technological advances for the laboratory; provided recommendations that increased laboratory throughput and reduced research cost by thousands of dollars.

 Designed training workshops for staff professional development which enhanced and shortened the learning curve.

 Coached and provided ongoing question-and-answer to pharmacology staff on surgical and cardiovascular techniques.

Genentech, Inc, South San Francisco, CA 1990 to 1999
Senior Research Associate, Cardiovascular Department

 Developed and implemented a model system, using a gamma camera to visualize the thrombolysis of a radioactively-labeled blood clot and for the study of embolic stroke. Designed models of stroke to study therapeutic intervention and neuroprotection.

 Designed and implemented a model to study intestinal ischemia/reperfusion injury; provided an exploratory alternative to the Second Generation Thrombolytic Team.

 Introduced and validated in vivo models to study embolic stroke; established collaboration with an academic laboratory to evaluate the therapeutic benefits of thrombolytics in stroke patients.

 Designed an in vivo model to investigate therapeutic intervention in ischemic stroke using a gamma camera imaging technique; explored the dose-response relationship of injected thrombolytics for the first time.

 Characterized the pathophysiology of focal ischemia using MRI; improved the process of investigating therapeutic intervention.

 Served as a member of the IACUC Committee for four years; guided the approval process of research protocols to achieve project goals and to comply with USDA regulations.

Education

Bachelor of Science, Biology College of Charleston, Charleston, South Carolina

Professional Development

Charles River Focus: Diagnostic Testing and Research Models (9 hours of CME)
Bioanalytical Systems, Inc Culex Workshop

Published Articles - 23

Poster Presentations - 4