Focal Ischemia Models

Many rodent models of focal ischemia are used in stroke research. These models can be used to determine the kinetics of thrombolysis, therapeutic intervention, characterization of the pathophysiology of ischemia and neuroprotection. Intraluminal model (middle cerebral artery occlusion), rat and mouse reperfusion models and embolic stroke models are available for training your laboratory staff.

Below is a list of publication which highlight the models mentioned in the previous paragraph:

“Optimized thrombolysis of cerebral clots with tissue-type plasminogen activator in a rabbit model of embolic stroke”, Thomas GR, Thibodeaux H, Bennett WF, Refino CJ, Badillo JM, Errett CJ, Zivin JA, J Pharmacol Exp Ther. 1993 Jan; 264(1): 67-73.

“A long-half-life and fibrin-specific form of tissue plasminogen activator in rabbit models of embolic stroke and peripheral bleeding”, Thomas GR, Thibodeaux H, Errett CJ, Badillo JM, Keyt BA, Refino CJ, Zivin JA, Bennett WF, Stroke. 1994 Oct; 25(10): 2072-8; discussion 2078-9.

“Secondary reduction in the apparent diffusion coefficient of water, increase in cerebral blood volume, and delayed neuronal death after middle cerebral artery occlusion and early reperfusion in the rat”, van Lookeren Campagne M, Thomas GR, Thibodeaux H, Palmer

 JT, Williams SP, Lowe DG, van Bruggen N, J Cereb Blood Flow Metab. 1999 Dec; 19(12): 1354-64.

“Transient focal cerebral ischemia induces sensorimotor deficits in mice”, Gerlai R, Thibodeaux H, Palmer JT, van Lookeren Campagne M, Van Bruggen N, Behav Brain Res. 2000 Feb; 108(1): 63-71.

“Evidence for a protective role of metallothionein-1 in focal cerebral ischemia”, van Lookeren Campagne M, Thibodeaux H, van Bruggen N, Cairns B, Gerlai R, Palmer JT, Williams SP, Lowe DG, Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22): 12870-5.

“Comparison of TNK with wild-type tissue plasminogen activator in a rabbit embolic stroke model”, Chapman DF, Lyden P, Lapchak PA, Nunez S, Thibodeaux H, Zivin J., Stroke. 2001 Mar; 32(3): 748-52.

“Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion”, Campagne MV, Thibodeaux H, van Bruggen N, Cairns B, Lowe DG, J Neurosci. 2000 Jul 15; 20(14): 5200-7.