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Consulting Services My services are intended to provide the resources to design and organize a preclinical laboratory and provide hands-on training to the laboratory staff. These hands-on techniques will build a foundation for success in both academics and/or drug development. Workshops to learn basic laboratory techniques, surgical techniques, anesthesia methods, how to write protocols and develop appropriate models to achieve academic and drug development goals will prepare your staff to achieve personal, project and corporate goals. A service to read final study reports to show documentation and validation is also available. Basic Laboratory Techniques By using my resources, your company or institution will be able to establish a stable foundation for a preclinical laboratory and accelerate the learning curve, which will result, into a well-trained staff. Your laboratory staff will be trained on the use of appropriate animal restraints; injection techniques, blood collection methods and basic necropsy for tissue harvest are essential elements to a successful program. More... Surgical Techniques Training to work with well-established cardiovascular models, to evaluate the efficacious and safety of novel and market drugs can be an important first step in many discovery programs. Rodent and guinea pig models are available to monitor the intrinsic activity of inhalation drugs, such as those used for asthma and/or COPD, drug screening protocols in normal animals as well as hypertensive models (spontaneously hypertensive rat (SHR), DOCA-Salt Sensitive). More... Cardiovascular Models Training to work with well-established cardiovascular models, to evaluate the efficacious and safety of novel and market drugs can be an important first step in many discovery programs. Rodent and guinea pig models are available to monitor the intrinsic activity of inhalation drugs, such as those used for asthma and/or COPD, drug screening protocols in normal animals as well as hypertensive models (spontaneously hypertensive rat (SHR), DOCA-Salt Sensitive). More... Focal Ischemia Models A search of the literature will result in describing many models of focal ischemia that have been utilized in stroke research. Intraluminal model (middle cerebral artery occlusion) and two rodent models are available for training your laboratory staff. Both rodent models (rat and mouse) are reperfusion models. Another specialized model, an embolic stroke model, is also available. These models can be used to determine the kinetics of thrombolysis, therapeutic intervention of various molecules, characterization of the pathophysiology of ischemia and neuroprotection. More... Selected Publications My preclinical science experience has been in both academia and the biopharmaceutical industry. I am including a short list of publications but a copy of selected publications and related papers can be provided upon request. Antiarrhythmic properties of chlordiazepoxide, Gillis RA, Thibodeaux H, Barr L, Circulation. 1974 Feb; 49(2): 272-82. Cerebrospinal fluid kinins and cardiovascular function. Effects of cerebroventricular melittin, Thomas GR, Thibodeaux H, Margolius HS, Privitera PJ, Hypertension. 1984 Mar-Apr; 6(2 Pt 2):I46-50 Optimized thrombolysis of cerebral clots with tissue-type plasminogen activator in a rabbit model of embolic stroke, Thomas GR, Thibodeaux H, Bennett WF, Refino CJ, Badillo JM, Errett CJ, Zivin JA, J Pharmacol Exp Ther. 1993 Jan; 264(1): 67-73 In vivo biological effects of various forms of thrombopoietin in a murine model of transient pancytopenia, Thomas GR, Thibodeaux H, Errett CJ, Mathias J, Marian M, Meng G, Vandlen RL, Eaton DL, Stem Cells. 1996; 14 Suppl 1:246-5 Limiting systemic plasminogenolysis reduces the bleeding potential for tissue-type plasminogen activators but not for streptokinase, Thomas GR, Thibodeaux H, Errett CJ, Badillo JM, Wu DT, Refino CJ, Keyt BA, Bennett WF, Thromb Haemost. 1996 Jun; 75(6): 915-20. Comparison of TNK with wild-type tissue plasminogen activator in a rabbit embolic stroke model, Chapman DF, Lyden P, Lapchak PA, Nunez S, Thibodeaux H, Zivin J., Stroke. 2001 Mar; 32(3): 748-52.
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